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S&DS Seminar: Bingxin Zhao (UPenn), “Analyzing genetic summary data: statistical models and platforms”

Monday, April 22, 2024    
4:00PM to 5:30PM
Yale Institute for Foundations of Data Science
Kline Tower 13th Floor, Room 1327
New Haven, CT 06511


Speaker: Bingxin Zhao
Assistant Professor, Statistics & Data Science
The Wharton School
University of Pennsylvania

Monday, April 22, 2024
3:30 pm: Tea Meet & Greet (Kitchen)
4:00 pm: Talk (Seminar Room #1327)
at the Yale institute for Foundations of Data Science, Kline Tower, 13th Floor

Information and Abstract: Summary statistics from extensive genetic and -omic research provide valuable biological insights into human complex traits and diseases, but also introduce new statistical, logistical, and computational challenges. In this talk, I will share our recent work in statistical models and computing infrastructures designed to address these interdisciplinary challenges in analyzing genetic summary data. This includes leveraging random matrix theory to understand the behavior of reference panel-based estimators in high-dimensional summary statistics from genome-wide association studies. I will further discuss the self-training of summary statistics, with applications to develop large-scale proteomic imputation models. In addition, I will introduce the BIGA platform (, a website based on cloud computing that offers unified data analysis pipelines and centralized data resources for accessible genetic summary data analysis.

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