People
Timothy Newhouse
Professor of Chemistry; Member of Wu Tsai Institute
Contact Information
Tim was born in New Hampshire and grew up in northern New England. He received his B.A. in Chemistry from Colby College (2005) in Waterville, ME, where he was mentored by Prof. Dasan M. Thamattoor. After moving to La Jolla, CA, he completed his Ph.D. at The Scripps Research Institute with Prof. Phil S. Baran (2010). During his time at Scripps, he also worked in the laboratories of Prof. Donna G. Blackmond. He then returned to the east coast for postdoctoral studies with Prof. E.J. Corey at Harvard University. He began his independent career at Yale in 2013, and is a Professor at Yale University in the Department of Chemistry and the Wu Tsai Institute.
What do you do with Data Science?
My group works on developing chemical technologies and computational approaches to enable the step-efficient synthesis of structurally complex natural products with potential applications to neuroscience. This research objective is benefited by a data science approach that leverages valuable data in chemical synthesis that remains underutilized. Recent publications that take advantage of a data science approach include: --Abbigayle E. Cuomo, Sebastian Ibarran, Sanil Sreekumar, Haote Li, Jungmin Eun, Jan Paul Menzel, Pengpeng Zhang, Frederic Buono, Jinhua J. Song, Robert H. Crabtree, Victor S. Batista*, Timothy R. Newhouse*. “Feed-Forward Neural Network for Predicting Enantioselectivity of the Asymmetric Negishi Reaction” ACS Cent. Sci. 2023, 9, 1768. --D. E. Kim, Y. Zhu, I. Aguilar, S. Harada, M. Wang and T. R. Newhouse.* “Total Synthesis of (+)-Shearilicine by a Computationally Enabled Heck Reaction” J. Am. Chem. Soc. 2023 145, 4394. --P. Zhang, J. Eun, M. Elkin, Y. Zhao, R. L. Cantrell, and T. R. Newhouse.* “A Neural Network Model Informs Total Synthesis of Clovane Sesquiterpenoids” Nature Synthesis 2023, 2, 527. --J. Eun, T. R. Newhouse* “Computational decoding” Nat. Rev. Chem. 2022, 6, 168–169. --D. E. Kim, J. E. Zweig, T. R. Newhouse.* “Total Synthesis of Paspaline A and Emindole PB Enabled by Computational Augmentation of a Transform-Guided Retrosynthetic Strategy” J. Am. Chem. Soc. 2019, 141, 1479.